Receptor Editing, Immune Diversification, and Self-Tolerance

Immune Receptor Editing Revise and Select

Secondary antigen receptor gene recombination occurs in developing lymphocytes, and in more mature T and B cells. In the developing lymphocyte, "editing" occurs in response to receptor ligation by autoantigens. As a result of receptor editing, anti-self-reactive cells are converted to non-self-reactive cells, and self-reactive clones are thereby salvaged before negative selection. This antigen-...

B cell receptor editing in tolerance and autoimmunity.

Receptor editing is the process of ongoing antibody gene rearrangement in a lymphocyte that already has a functional antigen receptor. The expression of a functional antigen receptor will normally terminate further rearrangement (allelic exclusion). However, lymphocytes with autoreactive receptors have a chance at escaping negative regulation by "editing" the specificities of their receptors wi...

Receptor editing as a mechanism of B cell tolerance.

An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

Understanding immune tolerance mechanisms is a major goal of immunology research, but mechanistic studies have generally required the use of mouse models carrying untargeted or targeted antigen receptor transgenes, which distort lymphocyte development and therefore preclude analysis of a truly normal immune system. Here we demonstrate an advance in in vivo analysis of immune tolerance that over...

Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects

Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...